6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

Base Information

Chemical Name:6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane
CAS No.:124268-80-0
Molecular Formula:C₂₇H₃₁ClN₂O₃
Molecular Weight:467.008
Hs Code.:

Synonyms:6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

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Chemical Property of 6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

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Technology Process of 6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

There total 4 articles about 6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124268-79-7
3-Benzyl-8a-((E)-4-hydroxy-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

: 124268-80-0
6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: With 2,3,5-trimethyl-pyridine; methanesulfonyl chloride; lithium chloride; In N,N-dimethyl-formamide; Yield given; Ambient temperature;

Reference yield:

: 124339-53-3
<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

: 124268-80-0
6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min

2: 91 percent / HF-pyridine complex / tetrahydrofuran / 2 h / Ambient temperature

3: collidine, LiCl, methanesulfonyl chloride / dimethylformamide / Ambient temperature

With 2,3,5-trimethyl-pyridine; pyridine hydrogenfluoride; methanesulfonyl chloride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 100-39-0
benzyl bromide

: 124268-80-0
6-<(2E)-4-chloro-3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-3-benzyl-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min

2: 91 percent / HF-pyridine complex / tetrahydrofuran / 2 h / Ambient temperature

3: collidine, LiCl, methanesulfonyl chloride / dimethylformamide / Ambient temperature

With 2,3,5-trimethyl-pyridine; pyridine hydrogenfluoride; methanesulfonyl chloride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;