(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

Base Information

Chemical Name:(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride
CAS No.:1375541-92-6
Molecular Formula:C₁₄H₁₅F₅N₂O₂*ClH
Molecular Weight:374.738
Hs Code.:

Synonyms:(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

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Chemical Property of (3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

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Technology Process of (3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

There total 4 articles about (3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375541-90-4
tert-butyl {(3S,5S)-5-(2,3-difluorophenyl)-2-oxo-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-3-yl}carbamate

: 1375541-92-6
(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 23 ℃; for 2h;

Reference yield:

: 145689-34-5
2-(2,3-difluorophenyl)acetonitrile

: 1375541-92-6
(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 0.83 h / 0 °C

2.1: hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 1.5 h / 2585.81 Torr

2.2: Chiral Pak_.(R). AD_.(R). column / Resolution of racemate

3.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.5 h / -30 °C

3.2: 2 h / -30 °C

4.1: hydrogenchloride / ethyl acetate / 2 h / 0 - 23 °C

With hydrogenchloride; hydrogen; sodium hydride; lithium hexamethyldisilazane; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: methyl 2-[(tert-butoxycarbonyl)amino]-4-cyano-4-(2,3-difluorophenyl)butanoate

: 1375541-92-6
(3S,5S)-3-amino-5-(2,3-difluorophenyl)-1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]piperidin-2-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 10 wt% Pd(OH)2 on carbon / methanol / 1.5 h / 2585.81 Torr

1.2: Chiral Pak_.(R). AD_.(R). column / Resolution of racemate

2.1: lithium hexamethyldisilazane / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / 0.5 h / -30 °C

2.2: 2 h / -30 °C

3.1: hydrogenchloride / ethyl acetate / 2 h / 0 - 23 °C

With hydrogenchloride; hydrogen; lithium hexamethyldisilazane; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate;