tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate
CAS No.:1375541-88-0
Molecular Formula:C₁₆H₂₀F₂N₂O₃
Molecular Weight:326.343
Hs Code.:

Synonyms:tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

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Chemical Property of tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

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Technology Process of tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

There total 7 articles about tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-[(tert-butoxycarbonyl)amino]-4-cyano-4-(2,3-difluorophenyl)butanoate

: 1375541-88-0
tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

Guidance literature:: methyl 2-[(tert-butoxycarbonyl)amino]-4-cyano-4-(2,3-difluorophenyl)butanoate; With hydrogen; 20% palladium hydroxide-activated charcoal; In methanol; for 1.5h; under 2585.81 Torr;

In hexanes; ethanol; diethylamine;

Reference yield:

: methyl 2-[(tert-butoxycarbonyl)amino]-4-cyano-4-(2,3-difluorophenyl)butanoate

: tert-butyl [(3R,5R)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

: 1375541-88-0
tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

Guidance literature:: methyl 2-[(tert-butoxycarbonyl)amino]-4-cyano-4-(2,3-difluorophenyl)butanoate; With hydrogen; 10 wt% Pd(OH)2 on carbon; In methanol; for 1.5h; under 2585.81 Torr;

With diethylamine; In hexanes; ethanol; Resolution of racemate;

Reference yield:

: 145689-34-5
2-(2,3-difluorophenyl)acetonitrile

: 1375541-88-0
tert-butyl [(3S,5S)-5-(2,3-difluorophenyl)-2-oxopiperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 0.83 h

2.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 1.5 h / 2585.81 Torr

2.2: Chiral Pak_.(R). AD_.(R). column

With hydrogen; sodium hydride; 20% palladium hydroxide-activated charcoal; In methanol; N,N-dimethyl-formamide; mineral oil;