N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide

Base Information

• Chemical Name: N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide
• CAS No.: 439112-52-4
• Molecular Formula: C₃₃H₄₁N₃O₆
• Molecular Weight: 575.705

Synonyms:N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide

Chemical Property of N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide

There total 2 articles about N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

O-benzylhydoxylamine hydrochloride (2687-43-6) + (2R,3S)-2-(benzyloxymethyl)-N-[(S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-3-(4-methoxyphenyl)succinamic acid (439112-51-3) → N1-benzyloxy-2(R)-benzyloxymethyl-N4-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide (439112-52-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jm0110993

Reference yield:

(S)-2-amino-3,3,N-trimethylbutyramide hydrochloride → N1-benzyloxy-2(R)-benzyloxymethyl-N4-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide (439112-52-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / HOBT; EDCI; triethylamine / dimethylformamide / 18 h / 20 °C

2: 100 percent / aq. NMM-N-oxide; OsO₄ / acetone; 2-methyl-propan-2-ol / 18 h / 20 °C

3: 100 percent / aq. NaIO₄ / acetone / 4 h / 20 °C

4: 46 percent / aq. NaClO₂; 2-methyl-2-butene; NaH₂PO₄ / 2-methyl-propan-2-ol / 18 h / 20 °C

5: 66 percent / HOBT; EDCI; triethylamine / dimethylformamide / 18 h / 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; 2-methyl-but-2-ene; benzotriazol-1-ol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; acetone; tert-butyl alcohol;

DOI:10.1021/jm0110993

Reference yield: 63.0%

N1-benzyloxy-2(R)-benzyloxymethyl-N4-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide (439112-52-4) → TNF484 (205807-59-6)

Guidance literature:

With hydrogen; Pd-BaSO₄; In methanol; for 6h; atmospheric pressure;

DOI:10.1021/jm0110993

upstream raw materials:

O-benzylhydoxylamine hydrochloride

(2R,3S)-2-(benzyloxymethyl)-N-[(S)-2,2-dimethyl-1-(methylcarbamoyl)propyl]-3-(4-methoxyphenyl)succinamic acid

Downstream raw materials:

TNF₄₈₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 439112-52-4 N¹-benzyloxy-2(R)-benzyloxymethyl-N⁴-(2,2-dimethyl-1(S)-methylcarbamoylpropyl)-3(S)-(4-methoxyphenyl)succinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send