phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester

Base Information

• Chemical Name: phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester
• CAS No.: 936910-18-8
• Molecular Formula: C₁₇H₁₉N₂O₄P
• Molecular Weight: 346.323
• Mol file: 936910-18-8.mol

Synonyms:phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester

Chemical Property of phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester

There total 6 articles about phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

diethyl chlorophosphate (814-49-3) + N-hydroxy-2-phenylbenzimidazole (5496-07-1,498539-13-2) → phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester (936910-18-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2007.04.058

Reference yield:

2-nitro-aniline (88-74-4) → phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester (936910-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 4 h / 80 °C

2: H₂ / Pd/C / methanol / 0.25 h

3: 67 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetlet.2007.04.058

Reference yield:

1-benzyloxy-2-phenylbenzimidazole (168209-86-7) → phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester (936910-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 0.25 h

2: 67 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.tetlet.2007.04.058

upstream raw materials:

diethyl chlorophosphate

N-hydroxy-2-phenylbenzimidazole

benzyl bromide

2-nitro-aniline

Downstream raw materials:

2-phenyl-1-[(phenylcarbonyl)oxy]-1H-benzimidazole