1H-Benzimidazole, 1-hydroxy-2-phenyl-

Base Information

• Chemical Name: 1H-Benzimidazole, 1-hydroxy-2-phenyl-
• CAS No.: 5496-07-1
• Molecular Formula: C13H10N2O
• Molecular Weight: 210.235
• Hs Code.: 2933990090
• Mol file: 5496-07-1.mol

Synonyms:2-phenyl-1-hydroxybenzimidazole;5-chloro-2-phenyl-1(3)H-benzoimidazole;2-phenyl-benzoimidazol-1-ol;1-Hydroxy-2-phenyl-benzimidazol;

Chemical Property of 1H-Benzimidazole, 1-hydroxy-2-phenyl-

Chemical Property:

• Melting Point: 225-226 °C
• Boiling Point: 444.1±28.0 °C(Predicted)
• PSA: 38.05000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.94060

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole, 1-hydroxy-2-phenyl-

There total 11 articles about 1H-Benzimidazole, 1-hydroxy-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-benzyloxy-2-phenylbenzimidazole (168209-86-7) → N-hydroxy-2-phenylbenzimidazole (5496-07-1,498539-13-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.25h;

DOI:10.1055/s-2007-965918

Reference yield: 73.0%

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) + benzylamine (100-46-9) → N-hydroxy-2-phenylbenzimidazole (5496-07-1,498539-13-2)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; potassium carbonate; at 155 ℃; for 3h; Microwave irradiation;

DOI:10.1080/00397911.2021.2001658

Reference yield:

benzyl bromide (100-39-0) + 2-nitro-aniline (88-74-4) → N-hydroxy-2-phenylbenzimidazole (5496-07-1,498539-13-2)

Guidance literature:

With NaH; In tetrahydrofuran; mineral oil;

upstream raw materials:

1-benzyloxy-2-phenylbenzimidazole

N-benzyloxyamine

2-phenyl-1-[(phenylcarbonyl)oxy]-1H-benzimidazole

ortho-nitrofluorobenzene

Downstream raw materials:

phosphoric acid diethyl ester 2-phenylbenzimidazol-1-yl ester

phosphoric acid diphenyl ester 2-phenylbenzimidazol-1-yl ester

diphenylphosphinic acid 2-phenylbenzimidazol-1-yl ester

2-phenyl-1-[(phenylcarbonyl)oxy]-1H-benzimidazole