Technology Process of 5-ethynyl-3-nitro-2-phenylethynyl-pyridine
There total 3 articles about 5-ethynyl-3-nitro-2-phenylethynyl-pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride; acetic acid;
In
tetrahydrofuran;
for 0.25h;
DOI:10.1016/j.tet.2003.09.004
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / sulfuric acid; fuming nitric acid / 3.5 h / 0 - 50 °C
2: hydrobromic acid; bromine; sodium nitrite / H2O
3: 1.32 g / copper(I) iodide; bis(triphenylphosphine)palladium(II) dichloride; diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C
4: 44 percent / copper(I) iodide; bis(triphenylphosphine)palladium(II) dichloride; diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C
5: 98 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 0.25 h
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen bromide; bromine; nitric acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
tetrahydrofuran; water;
3: Castro-Stephens/Sonogashira coupling / 4: Castro-Stephens/Sonogashira coupling;
DOI:10.1016/j.tet.2003.09.004
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 44 percent / copper(I) iodide; bis(triphenylphosphine)palladium(II) dichloride; diisopropylethylamine / tetrahydrofuran / 2 h / 20 °C
2: 98 percent / tetra-n-butylammonium fluoride; acetic acid / tetrahydrofuran / 0.25 h
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
1: Castro-Stephens/Sonogashira coupling;
DOI:10.1016/j.tet.2003.09.004
