Technology Process of (2R,3R)-(-)-2-phenethyl-3-benzylindoline
There total 6 articles about (2R,3R)-(-)-2-phenethyl-3-benzylindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methyl-N-((2-phenethyl-1H-indol-3-yl)(phenyl)methyl)benzenesulfonamide;
With
toluene-4-sulfonic acid;
In
dichloromethane; 2,2,2-trifluoroethanol;
at 20 ℃;
for 0.0833333h;
With
palladium(II) trifluoroacetate; hydrogen; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl;
In
dichloromethane; 2,2,2-trifluoroethanol;
at 50 ℃;
under 31029.7 Torr;
optical yield given as %ee;
enantioselective reaction;
Autoclave;
DOI:10.1039/c1ob06777j
- Guidance literature:
-
With
C46H41F3O2P2Pd; hydrogen; toluene-4-sulfonic acid;
In
dichloromethane; 2,2,2-trifluoroethanol;
at 20 ℃;
for 24h;
under 36201.3 Torr;
Autoclave;
Glovebox;
DOI:10.1021/ja502020b
- Guidance literature:
-
With
palladium(II) trifluoroacetate; hydrogen; toluene-4-sulfonic acid; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl;
In
dichloromethane; 2,2,2-trifluoroethanol;
at 50 ℃;
under 31029.7 Torr;
optical yield given as %ee;
enantioselective reaction;
Autoclave;
DOI:10.1002/chem.201100576
