(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

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Chemical Name:(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid
CAS No.:221526-01-8
Molecular Formula:C₃₈H₄₈N₄O₇
Molecular Weight:672.822
Hs Code.:

Synonyms:(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

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Chemical Property of (S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

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Technology Process of (S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

There total 9 articles about (S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 221525-87-7
(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

: 221526-01-8
(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1055/s-1999-2578

Reference yield:

: 24498-31-5
(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

: 221526-01-8
(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / HOBt, EDCI, TEA / CH₂Cl₂; tetrahydrofuran / 12 h / Ambient temperature

2: 72 percent / CF₃COOH / CHCl₃ / 12 h / Ambient temperature

3: 89 percent / bromotripyrrolinophosphonium hexafluorophosphate, DIEA / pyridine / 12 h / Heating

4: 56 percent / NaOH, H₂O / tetrahydrofuran / 12 h / Ambient temperature

With sodium hydroxide; TEA; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; chloroform;
DOI:10.1055/s-1999-2578

Reference yield:

: 42990-55-6,35016-63-8,42990-49-8,16503-53-0
(S)-(alpha)-bromobenzenepropanoic acid

: 221526-01-8
(S)-6-Benzyloxycarbonylamino-2-({(2R,3R)-1-[(S)-2-(4-hydroxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / CH₂Cl₂ / 48 h / Ambient temperature

2: 49 percent / HCl, H₂O / tetrahydrofuran / 12 h / Ambient temperature

3: 89 percent / bromotripyrrolinophosphonium hexafluorophosphate, DIEA / pyridine / 12 h / Heating

4: 56 percent / NaOH, H₂O / tetrahydrofuran / 12 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1055/s-1999-2578