(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester
CAS No.:221525-87-7
Molecular Formula:C₄₁H₅₂N₄O₈
Molecular Weight:728.886
Hs Code.:

(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Synonyms:(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

There total 7 articles about (S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 221525-79-7
(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionic acid

: 221525-71-9
(S)-6-Benzyloxycarbonylamino-2-[((2R,3R)-3-phenyl-pyrrolidine-2-carbonyl)-amino]-hexanoic acid methyl ester

: 221525-87-7
(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In pyridine; for 12h; Heating;
DOI:10.1055/s-1999-2578

Reference yield:

: 24498-31-5
(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

: 221525-87-7
(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / HOBt, EDCI, TEA / CH₂Cl₂; tetrahydrofuran / 12 h / Ambient temperature

2: 72 percent / CF₃COOH / CHCl₃ / 12 h / Ambient temperature

3: 89 percent / bromotripyrrolinophosphonium hexafluorophosphate, DIEA / pyridine / 12 h / Heating

With TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; chloroform;
DOI:10.1055/s-1999-2578

Reference yield:

: 42990-55-6,35016-63-8,42990-49-8,16503-53-0
(S)-(alpha)-bromobenzenepropanoic acid

: 221525-87-7
(S)-2-({(2R,3R)-1-[(S)-2-(4-Acetoxy-butylamino)-3-phenyl-propionyl]-3-phenyl-pyrrolidine-2-carbonyl}-amino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / CH₂Cl₂ / 48 h / Ambient temperature

2: 49 percent / HCl, H₂O / tetrahydrofuran / 12 h / Ambient temperature

3: 89 percent / bromotripyrrolinophosphonium hexafluorophosphate, DIEA / pyridine / 12 h / Heating

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1055/s-1999-2578