tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate
CAS No.:1432755-69-5
Molecular Formula:C₃₄H₃₉N₅O₇S
Molecular Weight:661.779
Hs Code.:

Synonyms:tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1232425-40-9
tert-butyl (5-bromo-3-(3-phenylisoxazol-5-yl)pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate

: 1427750-91-1
tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonylpiperidine-1-carboxylate

: 1432755-69-5
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium carbonate; at 65 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1432755-69-5
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / 3 h / 20 °C

4: potassium acetate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

5: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium carbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1432755-77-5
tert-butyl 3-((4-bromophenyl)thio)piperidine-1-carboxylate

: 1432755-69-5
tert-butyl 3-((4-(5-((tert-butoxycarbonyl)amino)-6-(3-phenylisoxazol-5-yl)pyrazin-2-yl)phenyl)sulfonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / 3 h / 20 °C

2: potassium acetate; (bis(tricyclohexyl)phosphine)palladium(II) dichloride / 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

3: sodium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1.5 h / 65 °C / Inert atmosphere

With (bis(tricyclohexyl)phosphine)palladium(II) dichloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium acetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane;