2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

Base Information

Chemical Name:2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione
CAS No.:75934-06-4
Molecular Formula:C₂₃H₂₄N₂O₄
Molecular Weight:392.455
Hs Code.:

Synonyms:2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

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Chemical Property of 2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

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Technology Process of 2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

There total 9 articles about 2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75961-46-5
2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

: 1074-82-4
potassium phtalimide

: 75934-06-4
2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jo00317a027

Reference yield: 95.0%

: C₁₆H₂₃NO₅S

: 1074-82-4
potassium phtalimide

: 75934-06-4
2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jo00317a027

Reference yield:

: 119-36-8,8024-54-2
methyl salicylate

: 75934-06-4
2-{3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propyl}-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetone / 60 h

2: sodium hydride / 1) 20 min at 0 deg C 2) reflux for 12 h

3: sodium hydroxide / 1) 1h reflux with NaOH 2) concentrated HCl

4: thionyl chloride

5: sodium hydroxide; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide / 2) at 55-60 deg C for 90 min

6: triethylamine / dichloromethane / 2.5 h / Ambient temperature

7: N,N-dimethyl-formamide / 2 h / 60 °C

With sodium hydroxide; thionyl chloride; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00317a027