2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:75961-46-5
Molecular Formula:C₁₆H₂₃NO₄S
Molecular Weight:325.429
Hs Code.:

Synonyms:2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

There total 7 articles about 2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 75934-05-3
3-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-propan-1-ol

: 124-63-0
methanesulfonyl chloride

: 75961-46-5
2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With triethylamine; In dichloromethane; for 2.5h; Ambient temperature;
DOI:10.1021/jo00317a027

Reference yield:

: 119-36-8,8024-54-2
methyl salicylate

: 75961-46-5
2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / K₂CO₃ / acetone / 60 h

2: 99.8 percent / 15 h / Heating

3: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h

4: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl

5: SOCl₂

6: 1) BF₃*THF 2) NaOH, 30percent H₂O₂ / 2) at 55-60 deg C for 90 min

7: 88 percent / triethylamine / CH₂Cl₂ / 2.5 h / Ambient temperature

With sodium hydroxide; thionyl chloride; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; sodium hydride; potassium carbonate; triethylamine; In dichloromethane; acetone;
DOI:10.1021/jo00317a027

Reference yield:

: 6282-42-4
methyl 2-allyloxybenzoate

: 75961-46-5
2-[3-(3-Methanesulfonyl-propyl)-2-methoxy-phenyl]-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 99.8 percent / 15 h / Heating

2: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h

3: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl

4: SOCl₂

5: 1) BF₃*THF 2) NaOH, 30percent H₂O₂ / 2) at 55-60 deg C for 90 min

6: 88 percent / triethylamine / CH₂Cl₂ / 2.5 h / Ambient temperature

With sodium hydroxide; thionyl chloride; boron trifluoride-tetrahydrofuran complex; dihydrogen peroxide; sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/jo00317a027