3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Base Information

Chemical Name:3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid
CAS No.:99198-18-2
Molecular Formula:C₂₁H₂₈N₂O₆
Molecular Weight:404.463
Hs Code.:

Synonyms:3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

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Chemical Property of 3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

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Technology Process of 3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

There total 6 articles about 3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 97871-14-2
3(S)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

: 99198-18-2
3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: With sodium hydroxide; In ethanol; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 10094-36-7
ethyl 3-cyclohexylpropanoate

: 99198-18-2
3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

2: 19 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

3: 99 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

4: 76 percent / 1 N NaOH / ethanol / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium chloride; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1248/cpb.34.1128

Reference yield:

: 6048-09-5
3-cyclohexylacrylic acid ethyl ester

: 99198-18-2
3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

2: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

3: 19 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 99 percent / H₂ / 10 percent Pd-C / ethanol / Ambient temperature

5: 76 percent / 1 N NaOH / ethanol / Ambient temperature

With sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; sodium chloride; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1248/cpb.34.1128