5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE

Base Information

• Chemical Name: 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE
• CAS No.: 116750-06-2
• Molecular Formula: C14H9 N O4
• Molecular Weight: 255.23
• Hs Code.: 2932190090
• Mol file: 116750-06-2.mol

Synonyms:NSC 119558

Chemical Property of 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE

Chemical Property:

• Vapor Pressure: 1.91E-08mmHg at 25°C
• Melting Point: 125 °C
• Refractive Index: 1.674
• Boiling Point: 454.4°Cat760mmHg
• PKA: -2.53±0.20(Predicted)
• Flash Point: 228.6°C
• PSA: 67.59000
• Density: 1.455g/cm³
• LogP: 1.82620

Purity/Quality:

98%min ^*data from raw suppliers

5-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-2-furaldehdye ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE

There total 4 articles about 5-[(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)METHYL]-2-FURALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

5-chloromethylfurfural (1623-88-7) + potassium phtalimide (1074-82-4) → 5-(1,3-dioxo-2,3-dihydro-1H-2-isoindolylmethyl)-2-furaldehyde (116750-06-2)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 3h; Temperature;

Reference yield: 86.0%

5-phthalimidomethyl-2-(2-dioxolanyl)furan → 5-(1,3-dioxo-2,3-dihydro-1H-2-isoindolylmethyl)-2-furaldehyde (116750-06-2)

Guidance literature:

With pyridine hydrochloride; In acetone; for 0.25h; Heating;

DOI:10.1055/s-1995-3897

Reference yield: 83.0%

2-(furan-2-ylmethyl)isoindoline-1,3-dione (4667-83-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-(1,3-dioxo-2,3-dihydro-1H-2-isoindolylmethyl)-2-furaldehyde (116750-06-2)

Guidance literature:

With trichlorophosphate; at 20 - 50 ℃;

DOI:10.1007/s10593-007-0058-1

upstream raw materials:

2-(furan-2-ylmethyl)isoindoline-1,3-dione

N,N-dimethyl-formamide

furan-2-ylmethanamine

5-chloromethylfurfural

Refernces

• 1、 -. "Process for preparing 5-aminolevulinic acid from 5-chloromethyl furfural". Paragraph 0025; 0027-0028; 0036-0038; 0045-0047; 0054-0056. . Retrieved 2019/10/29.
• 2、 Cottier,Descotes,Eymard,Rapp. "Syntheses of γ-oxo acids or γ-oxo esters by photooxygenation of furanic compounds and reduction under ultrasound: Application to the synthesis of 5-aminolevulinic acid hydrochloride". . p. 303 - 306. Retrieved 2007/10/02.