2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1443684-48-7
Molecular Formula:C₂₃H₁₆F₂N₄S
Molecular Weight:418.47
Hs Code.:

Synonyms:2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

There total 10 articles about 2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.2%

: 1279106-04-5
trifluoro-methanesulfonic acid 5-ethyl-2-pyridin-3-yl-thiazol-4-yl ester

: 1443684-79-4
2-(2,6-difluoro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1443684-48-7
2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 3h;

Reference yield:

: 1443684-76-1
5-bromo-2-(2,6-difluoro-phenyl)-1H-pyrrolo[2,3-b]pyridine

: 1443684-48-7
2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; water; 2: |Suzuki Coupling;

Reference yield:

: 183208-32-4
3,3,5-Tribromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

: 1443684-48-7
2-(2,6-difluoro-phenyl)-5-(5-ethyl-2-pyridin-3-yl-thiazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc; acetic acid / water / 3 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: ammonium carbonate / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 1 h / 100 °C

6.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C

7.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 3 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; ammonium carbonate; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5.1: |Suzuki Coupling / 7.1: |Suzuki Coupling;