1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

Base Information

Chemical Name:1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea
CAS No.:1012877-26-7
Molecular Formula:C₂₄H₁₉ClF₃N₅O₂
Molecular Weight:501.895
Hs Code.:

Synonyms:1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

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Chemical Property of 1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

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Technology Process of 1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

There total 13 articles about 1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1012878-92-0
3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one

: 4519-39-5
2,3-difluorobenzoic acid

: 1012877-26-7
1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 1012878-91-9
3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1012877-26-7
1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 200 °C / Sealed tube

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3: diphenylphosphoranyl azide; triethylamine / 1,4-dioxane / 0.5 h / 20 °C

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1442470-43-0
7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1012877-26-7
1-(4-chloro-5-(1-ethyl-7-( methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-(2,3-difluorophenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

2: diphenylphosphoranyl azide; triethylamine / 1,4-dioxane / 0.5 h / 20 °C

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;