N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide

Base Information

• Chemical Name: N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide
• CAS No.: 282100-06-5
• Molecular Formula: C₄₁H₄₀FN₃O₆S
• Molecular Weight: 721.85

Synonyms:N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide

Chemical Property of N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide

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Technology Process of N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide

There total 1 articles about N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(2S)-2-[[(2R)-2-(3-amino-4-benzyloxyphenyl)-2-hydroxyethyl]benzylamino]-3-[4-(6-fluoroquinolin-4-yloxy)phenyl]propan-1-ol (282100-05-4) + methanesulfonyl chloride (124-63-0) → N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide (282100-06-5)

Guidance literature:

With pyridine; In dichloromethane;

Reference yield: 68.0%

N-[5-[(1R)-2-[benzyl-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethyl]-amino]-1-hydroxyethyl]-2-benzyloxyphenyl]methanesulfonamide (282100-06-5) + palladium (7440-05-3) → N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[(1S)-1-[4-(6-fluoroquinolin-4-yloxy)benzyl]-2-hydroxyethylamino]ethyl]phenyl]methanesulfonamide

Guidance literature:

In methanol;

upstream raw materials:

(2S)-2-[[(2R)-2-(3-amino-4-benzyloxyphenyl)-2-hydroxyethyl]benzylamino]-3-[4-(6-fluoroquinolin-4-yloxy)phenyl]propan-1-ol

methanesulfonyl chloride

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