(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

Base Information

Chemical Name:(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine
CAS No.:252953-39-2
Molecular Formula:C₂₈H₄₁NO₄Si
Molecular Weight:483.723
Hs Code.:

Synonyms:(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

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Chemical Property of (R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

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Technology Process of (R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

There total 4 articles about (R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 77-76-9
2,2-dimethoxy-propane

: 252953-38-1
(R)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyldiphenylsilyl)oxy)-2-methyl-1-propanol

: 252953-39-2
(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1021/jo990957o

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 252953-39-2
(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / imidazole / dimethylformamide / 48 h / 25 °C

2: 71 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3: 94 percent / p-toluenesulfonic acid / toluene / Heating

With 1H-imidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; 1: silylation / 2: Reduction / 3: Cyclization;
DOI:10.1021/jo990957o

Reference yield:

: 188476-24-6
2,2-Dimethyl-propionic acid (S)-2-tert-butoxycarbonylamino-3-hydroxy-2-methyl-propyl ester

: 252953-39-2
(R)-N-(tert-butoxycarbonyl)-4-((tert-butyldiphenylsilyloxy)methyl)-2,2,4-trimethyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / imidazole / dimethylformamide / 48 h / 25 °C

2: 71 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3: 94 percent / p-toluenesulfonic acid / toluene / Heating

With 1H-imidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; In dichloromethane; N,N-dimethyl-formamide; toluene; 1: silylation / 2: Reduction / 3: Cyclization;
DOI:10.1021/jo990957o