H-β³-hPhe-N-allyl-β³-hPhe-OMe

Base Information

Chemical Name:H-β³-hPhe-N-allyl-β³-hPhe-OMe
CAS No.:312311-60-7
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

H-β<sup>3</sup>-hPhe-N-allyl-β<sup>3</sup>-hPhe-OMe

Synonyms:H-β³-hPhe-N-allyl-β³-hPhe-OMe

Suppliers and Price of H-β³-hPhe-N-allyl-β³-hPhe-OMe

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-β³-hPhe-N-allyl-β³-hPhe-OMe

Chemical Property:

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Technology Process of H-β³-hPhe-N-allyl-β³-hPhe-OMe

There total 13 articles about H-β³-hPhe-N-allyl-β³-hPhe-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 312311-70-9
methyl N-(p-nitrobenzenesulfonyl)-(S)-β³-homophenylalanyl-N-allyl-(S)-β³-homophenylalaninate

: 312311-60-7
H-β³-hPhe-N-allyl-β³-hPhe-OMe

Guidance literature:: With mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; for 16h;
DOI:10.1016/S0040-4020(00)00666-9

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 312311-60-7
H-β³-hPhe-N-allyl-β³-hPhe-OMe

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / CH₂Cl₂ / 10 h / 20 °C

1.2: 95 percent / KOH / H₂O

2.1: H₂O; acetonitrile / 16 h / 20 °C

3.1: 40.98 g / H₂O; HCl / acetic acid / 4 h / Heating

4.1: 90 percent / PTSA / 20 h / Heating

5.1: K₂CO₃ / dimethylformamide; H₂O / 18 h / 20 °C

6.1: 2.15 g / mercaptoacetic acid; DBU / dimethylformamide; H₂O / 3 h

7.1: 4.26 g / pyridine / tetrahydrofuran / 2 h / 20 °C

8.1: 88 percent / mercaptoacetic acid; DBU / dimethylformamide / 16 h

With pyridine; hydrogenchloride; water; potassium carbonate; toluene-4-sulfonic acid; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1.1: Substitution / 1.2: Cyclization / 2.1: Addition / 3.1: Hydrolysis / 4.1: Esterification / 5.1: Alkylation / 6.1: Substitution / 7.1: Acylation / 8.1: Substitution;
DOI:10.1016/S0040-4020(00)00666-9

Reference yield:

: 219738-95-1
(S)-N-(p-nitrobenzenesulfonyl)-2-benzylaziridine

: 312311-60-7
H-β³-hPhe-N-allyl-β³-hPhe-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: H₂O; acetonitrile / 16 h / 20 °C

2: 40.98 g / H₂O; HCl / acetic acid / 4 h / Heating

3: 90 percent / PTSA / 20 h / Heating

4: K₂CO₃ / dimethylformamide; H₂O / 18 h / 20 °C

5: 2.15 g / mercaptoacetic acid; DBU / dimethylformamide; H₂O / 3 h

6: 4.26 g / pyridine / tetrahydrofuran / 2 h / 20 °C

7: 88 percent / mercaptoacetic acid; DBU / dimethylformamide / 16 h

With pyridine; hydrogenchloride; water; potassium carbonate; toluene-4-sulfonic acid; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; acetonitrile; 1: Addition / 2: Hydrolysis / 3: Esterification / 4: Alkylation / 5: Substitution / 6: Acylation / 7: Substitution;
DOI:10.1016/S0040-4020(00)00666-9