4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide
CAS No.:1331882-41-7
Molecular Formula:C₂₃H₁₈Cl₂F₆N₂O₃
Molecular Weight:555.304
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

There total 13 articles about 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1231755-16-0
[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]ammonium 2,2,2-trifluoroacetate

: 1331886-78-2
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

: 1331882-41-7
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

Guidance literature:: 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]ammonium 2,2,2-trifluoroacetate; With dicyclohexyl-carbodiimide; In dichloromethane; for 79.92h;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1331882-41-7
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

1.2: 0.5 h / 2 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

4.2: 1-hydroxyazabenzotriazole / 79.92 h

With oxalyl dichloride; triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In dichloromethane; toluene;

Reference yield:

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1331882-41-7
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-N-[(2,2,2-trifluoro-ethylcarbamoyl)-methyl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

3.1: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

3.2: 1-hydroxyazabenzotriazole / 79.92 h

With triethylamine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene;