4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid
CAS No.:1331886-78-2
Molecular Formula:C₁₉H₁₃Cl₂F₃O₃
Molecular Weight:417.212
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

There total 13 articles about 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331886-77-1
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid tert-butyl ester

: 1331886-78-2
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1331886-78-2
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

1.2: 0.5 h / 2 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With oxalyl dichloride; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In dichloromethane; toluene;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1331886-78-2
4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-2,5-dihydro-furan-3-yl]-2-methyl-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethyl bromide; magnesium / tetrahydrofuran / 0.67 h / 0 - 20 °C

1.2: 0 °C

2.1: tetrabutyl ammonium fluoride / ethyl acetate; tetrahydrofuran / 22 h / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.75 h / Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

5.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8.2 h / 20 °C / Inert atmosphere; Reflux

6.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With ethyl bromide; tetrabutyl ammonium fluoride; magnesium; triphenylphosphine; trifluoroacetic acid; lithium chloride; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;