(±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal

Base Information

• Chemical Name: (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal
• CAS No.: 110598-66-8
• Molecular Formula: C₁₆H₂₆O₂Si
• Molecular Weight: 278.467
• Mol file: 110598-66-8.mol

Synonyms:(±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal

Chemical Property of (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal

There total 19 articles about (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyronitrile (182226-22-8) → (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal (110598-66-8)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h; pH₄ tartaric-buffer work-up;

DOI:10.1016/0040-4039(96)01270-1

Reference yield: 94.0%

3-tert-butyldimethylsilyloxy-5-phenyl-1-pentene (73795-11-6) → (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal (110598-66-8)

Guidance literature:

With ozone; triphenylphosphine; In dichloromethane; at -78 - 25 ℃; Inert atmosphere;

DOI:10.1039/d1ob02126e

Reference yield: 86.0%

C18H18O3 + t-butyldimethylsiyl triflate (69739-34-0) → (±)-2-((tert-butyldimethylsilyl)oxy)-4-phenylbutanal (110598-66-8)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 50 ℃; for 0.5h; under 3102.97 Torr; Sealed vessel; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.06.142

upstream raw materials:

2-(tert-Butyl-dimethyl-silanyloxy)-4-phenyl-butyronitrile

1-(2-phenylethyl)-but-3-en-1-yl tert-butyldimethylsilyl ether

3-<(tert-butyldimethylsilyl)oxy>-5-phenylpentanal

3-phenyl-propionaldehyde

Downstream raw materials:

2-methoxy-4-phenylbutanal

C₃₁H₄₂O₂Si₂