182226-22-8Relevant academic research and scientific papers
Remarkable acceleration of cyanosilylation by the mesoporous Al-MCM-41 catalyst
Iwanami, Katsuyuki,Choi, Jun-Chul,Lu, Baowang,Sakakura, Toshiyasu,Yasuda, Hiroyuki
, p. 1002 - 1004 (2008)
The presence of the heterogeneous mesoporous Al-MCM-41 catalyst remarkably accelerated the cyanosilylation of various aldehydes and ketones with trialkylsilyl cyanide, giving the corresponding cyanohydrin silyl ethers in quantitative yields under mild reaction conditions. The Royal Society of Chemistry.
P(RNCH2CH2)N: Efficient catalysts for the cyanosilylation of aldehydes and ketones
Fetterly, Brandon M.,Verkade, John G.
, p. 8061 - 8066 (2007/10/03)
The 1,2-addition of trialkylsilylcyanides to aldehydes and ketones produces the corresponding protected cyanohydrins in good to excellent yields when carried out at 0°C to room temperature in the presence of catalytic amounts of the nonionic strong base P(RNCH2CH2)N (R = Me, i-Pr) in THF. These catalysts are easily removed from the product by hydrolysis or column filtration through silica gel.
Improved conditions for the Kiliani-Fischer synthesis
Adje,Vogeleisen,Uguen
, p. 5893 - 5896 (2007/10/03)
DIBA-H reduction of O-TBDMS derivatives of cyanohydrins, followed by hydrolysis with a pH4 tartaric-buffer at low temperature produces the corresponding O-protected 2-hydroxy aldehydes in very high yields.
