(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

Base Information

Chemical Name:(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide
CAS No.:350245-17-9
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

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Technology Process of (R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

There total 1 articles about (R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 930-21-2
2-azetidinone

: 68856-96-2
N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine

: 350245-17-9
(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 1.33333h;
DOI:10.1021/jo0302197

Reference yield:

: 350245-17-9
(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

: 162473-78-1
desepoxyarenastatin A

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / dioxane / 1.5 h

2: 64 percent / DIEA; HBTU / acetonitrile / 2 h / 0 - 20 °C

3: 88 percent / BF₃*Et₂O / CHCl₃ / 1 h

4: 68 percent / Bu₄NCN / CH₂Cl₂ / 16 h

5: 31 percent / Et₃N / Pd(OAc)2 / acetonitrile / 20 h / 80 - 85 °C

With hydrogenchloride; boron trifluoride diethyl etherate; tetra-n-butylammonium cyanide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; acetonitrile; 5: Heck reaction;
DOI:10.1021/jo0302197

Reference yield:

: 350245-17-9
(R)-(tert-butoxy)-(N-1-((4-methoxyphenyl)methyl)-2-oxo-2-(2-oxoazetidinyl)ethyl)formamide

: 162600-54-6
cryptophycin-24

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / dioxane / 1.5 h

2: 64 percent / DIEA; HBTU / acetonitrile / 2 h / 0 - 20 °C

3: 88 percent / BF₃*Et₂O / CHCl₃ / 1 h

4: 68 percent / Bu₄NCN / CH₂Cl₂ / 16 h

5: 31 percent / Et₃N / Pd(OAc)2 / acetonitrile / 20 h / 80 - 85 °C

6: dimethyldioxirane / acetone

With hydrogenchloride; boron trifluoride diethyl etherate; tetra-n-butylammonium cyanide; 3,3-dimethyldioxirane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium diacetate; In 1,4-dioxane; dichloromethane; chloroform; acetone; acetonitrile; 5: Heck reaction;
DOI:10.1021/jo0302197