8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Base Information

Chemical Name:8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
CAS No.:98634-69-6
Molecular Formula:C₂₁H₂₃F₂N₃
Molecular Weight:355.431
Hs Code.:

Synonyms:8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

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Chemical Property of 8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

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Technology Process of 8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

There total 3 articles about 8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58039-14-8
4-[8-fluoro-5-(4-fluoro-phenyl)-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-butyronitrile

: 98634-69-6
8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1.5h;
DOI:10.1021/jm00151a002

Reference yield:

: 58038-68-9
8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

: 98634-69-6
8-fluoro-5-(4-fluorophenyl)-2-(4-amino-1-butyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃, KI / various solvent(s) / 1.) from 80 deg C to 90 deg C, 18 h, 2.) from 120 deg C to 130 deg C, 72 h

2: LiAlH₄ / diethyl ether / 1.5 h

With lithium aluminium tetrahydride; sodium carbonate; potassium iodide; In diethyl ether;
DOI:10.1021/jm00151a002