Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester

Base Information

• Chemical Name: Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester
• CAS No.: 863012-01-5
• Molecular Formula: C₁₉H₂₁O₇PS
• Molecular Weight: 424.411

Synonyms:Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester

Chemical Property of Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester

There total 3 articles about Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(2S,4R,5S,6R)-2-phenoxy-6-[(phenylmethoxy)methyl]-1,2-oxaphosphorinane-4,5-diol 2-oxide (863011-99-8) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ5-[1,2]oxaphosphinin-5-yl ester (863012-01-5)

Guidance literature:

With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo0505122

Reference yield:

(2S,6S)-6-Benzyloxymethyl-2-phenoxy-3,6-dihydro-[1,2]oxaphosphinine 2-oxide (863011-98-7) → Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ5-[1,2]oxaphosphinin-5-yl ester (863012-01-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / m-CPBA; N-methylmorpholine; citric acid / OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 48 h

2: 83 percent / Et₃N / DMAP / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; triethylamine; 3-chloro-benzenecarboperoxoic acid; citric acid; dmap; osmium(VIII) oxide; In dichloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1021/jo0505122

Reference yield:

Allyl-phosphonic acid (S)-1-benzyloxymethyl-allyl ester phenyl ester → Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ5-[1,2]oxaphosphinin-5-yl ester (863012-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / (PCy₃)2Cl₂Ru=CHPh / CH₂Cl₂ / Heating

2: 84 percent / m-CPBA; N-methylmorpholine; citric acid / OsO₄ / acetone; 2-methyl-propan-2-ol; H₂O / 48 h

3: 83 percent / Et₃N / DMAP / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; triethylamine; 3-chloro-benzenecarboperoxoic acid; citric acid; dmap; osmium(VIII) oxide; Grubbs catalyst first generation; In dichloromethane; water; acetone; tert-butyl alcohol;

DOI:10.1021/jo0505122

upstream raw materials:

(2S,4R,5S,6R)-2-phenoxy-6-[(phenylmethoxy)methyl]-1,2-oxaphosphorinane-4,5-diol 2-oxide

methanesulfonyl chloride

(2S,6S)-6-Benzyloxymethyl-2-phenoxy-3,6-dihydro-[1,2]oxaphosphinine 2-oxide

Downstream raw materials:

(2S,5R,6S)-5-Azido-6-benzyloxymethyl-2-phenoxy-5,6-dihydro-[1,2]oxaphosphinine 2-oxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 863012-01-5 Methanesulfonic acid (2S,5S,6R)-6-benzyloxymethyl-2-oxo-2-phenoxy-5,6-dihydro-2H-2λ⁵-[1,2]oxaphosphinin-5-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send