2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

Base Information

Chemical Name:2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile
CAS No.:956005-70-2
Molecular Formula:C₁₅H₂₇NOSi
Molecular Weight:265.471
Hs Code.:

Synonyms:2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

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Technology Process of 2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

There total 5 articles about 2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 956005-64-4
((1S,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)methyl iodide

: 151-50-8
potassium cyanide

: 956005-70-2
2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 40 ℃; for 12h;
DOI:10.1021/ol7017938

Reference yield: 96.0%

: potassium cyanide

: 956005-64-4
((1S,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)methyl iodide

: 956005-70-2
2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 40 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo2026349

Reference yield:

: 956005-60-0
((1S,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)methanol

: 956005-70-2
2-((1R,6S)-6-((tert-butyldimethylsilyloxy)methyl)cyclohex-3-enyl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / imidazole; PPh₃; I₂ / CH₂Cl₂ / 0.42 h

2: 96 percent / dimethylsulfoxide / 12 h / 40 °C

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol7017938