4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

Base Information

Chemical Name:4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester
CAS No.:123043-94-7
Molecular Formula:C₁₈H₂₂N₂O₄S
Molecular Weight:362.45
Hs Code.:

Synonyms:4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

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Technology Process of 4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

There total 6 articles about 4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 541-41-3
chloroformic acid ethyl ester

: 74840-45-2
6-methyl-2-methylthio-4-phenyl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

: 123043-94-7
4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

Guidance literature:: With pyridine; In tetrahydrofuran; for 0.5h; Ambient temperature;

Reference yield: 60.0%

: 541-41-3
chloroformic acid ethyl ester

: 74840-45-2
ethyl 6-methyl-2-methylthio-4-phenyl-3,4,5,6-tetrahydropyrimidine-5-carboxylate

: 123043-94-7
4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 5 ℃; for 7h;
DOI:10.1246/bcsj.65.2246

Reference yield:

: 123043-88-9,33458-26-3
5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

: 123043-94-7
4-methyl-2-methylthio-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / methanol / 3 h / Heating

2: 60 percent / Et₃N / CH₂Cl₂ / 7 h / 5 °C

With triethylamine; In methanol; dichloromethane;
DOI:10.1246/bcsj.65.2246