benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

Base Information

Chemical Name:benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate
CAS No.:136019-52-8
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

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Chemical Property of benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

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Technology Process of benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

There total 5 articles about benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 134558-10-4
1-<(1,1-dimethylethoxy)carbonyl>-N-formyl-DL-tryptophan benzyl ester

: 136019-52-8
benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

Guidance literature:: With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; for 10h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86480-2

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 136019-52-8
benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / Ambient temperature

2: 87 percent / Et₃N, triphosgene / CH₂Cl₂ / 10 h / Ambient temperature

With dmap; bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86480-2

Reference yield:

: 100-39-0
benzyl bromide

: 136019-52-8
benzyl-(+/-)-α-cyano-1-<(1,1-dimethylethoxy)carbonyl>-1H-indole-3-propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Cs₂CO₃ / 1.) H₂O 2.) DMF, 4 h

2: 68 percent / 4-dimethylaminopyridine / dimethylformamide / 24 h / Ambient temperature

3: 87 percent / Et₃N, triphosgene / CH₂Cl₂ / 10 h / Ambient temperature

With dmap; bis(trichloromethyl) carbonate; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86480-2