N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

Base Information

Chemical Name:N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide
CAS No.:1026705-78-1
Molecular Formula:C₃₆H₅₃N₇O₄
Molecular Weight:647.861
Hs Code.:

<i>N</i>-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-<i>N</i>',<i>N</i>'-dipropyl-isophthalamide

Synonyms:N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

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Chemical Property of N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

Chemical Property:

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Technology Process of N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

There total 12 articles about N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637024-85-2
(2R,4S,5S)-4-Azido-5-(3-dipropylcarbamoyl-benzoylamino)-2,7-dimethyl-octanoic acid

: 106566-02-3,120369-25-7,144902-31-8
L-valine benzylamide

: 1026705-78-1
N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0509142

Reference yield:

: [(S)-3-Methyl-1-((R)-4-methyl-5-oxo-2,5-dihydro-furan-2-yl)-butyl]-carbamic acid tert-butyl ester

: 1026705-78-1
N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Pd/C / tetrahydrofuran

2: LiAlH₄ / tetrahydrofuran; 1,2-dimethoxy-ethane / 0 - 20 °C

3: imidazole / CH₂Cl₂ / 0 °C

4: triethylamine / CHCl₃ / 0 °C

5: NaN₃ / dimethylformamide / 60 °C

6: HCl / dioxane

7: diisopropylethylamine; HOBt; EDC / dimethylformamide / 20 °C

8: Jones' reagent / acetone / 20 °C

9: diisopropylethylamine; HATU / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; sodium azide; jones' reagent; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0509142

Reference yield:

: (Z)-(S)-5-tert-Butoxycarbonylamino-2,7-dimethyl-4-oxo-oct-2-enoic acid ethyl ester

: 1026705-78-1
N-[2-azido-4-(1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-isobutyl-pentyl]-N',N'-dipropyl-isophthalamide

Guidance literature:: Multi-step reaction with 10 steps

1: NaBH₄ / methanol / -78 - -15 °C

2: H₂ / Pd/C / tetrahydrofuran

3: LiAlH₄ / tetrahydrofuran; 1,2-dimethoxy-ethane / 0 - 20 °C

4: imidazole / CH₂Cl₂ / 0 °C

5: triethylamine / CHCl₃ / 0 °C

6: NaN₃ / dimethylformamide / 60 °C

7: HCl / dioxane

8: diisopropylethylamine; HOBt; EDC / dimethylformamide / 20 °C

9: Jones' reagent / acetone / 20 °C

10: diisopropylethylamine; HATU / dimethylformamide / 20 °C

With 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; jones' reagent; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0509142