10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

Base Information

Chemical Name:10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
CAS No.:936833-38-4
Molecular Formula:C₁₉H₁₈N₄O₂
Molecular Weight:334.378
Hs Code.:
ChEMBL ID:CHEMBL235157
DSSTox Substance ID:DTXSID80590833
Metabolomics Workbench ID:150117
Wikidata:Q27095837

Synonyms:936833-38-4;10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine;10,11-Dimethoxy-4-methyldibenzo[c,f][2,7]naphthyridine-3,6-diamine;Kinome_3774;2r7b;CHEMBL235157;SCHEMBL4984241;BDBM19087;DTXSID80590833;Dibenzo[c,f][2,7]naphthyridine, 1;DB06932;PD005768;NS00071227;Q27095837;15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8.0.0(2),.0(1)(3),(1)]octadeca-1(10),2,4,6,8,11,13,15,17-nonaene-5,9-diamine;15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8.0.0,.0,octadeca-1(10),2,4,6,8,11,13,15,17-nonaene-5,9-diamine;15,16-dimethoxy-6-methyl-8,12-diazatetracyclo[8.8.0.0;{2,7}.0;{13,18}]octadeca-1(10),2(7),3,5,8,11,13,15,17-nonaene-5,9-diamine

Suppliers and Price of 10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:334.14297583
Heavy Atom Count:25
Complexity:478

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC2=C3C4=CC(=C(C=C4N=CC3=C(N=C12)N)OC)OC)N

Technology Process of 10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

There total 3 articles about 10,11-Dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 823-40-5
2,6-toluenediamine

: 214470-55-0
4-chloro-6,7-dimethoxyquinoline-3-carbonitrile

: 936833-38-4
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

: 4-[(3-amino-2-methylphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile

Guidance literature:: With pyridine hydrochloride; In 2-ethoxy-ethanol; at 210 ℃; for 1h; Temperature; Time; Concentration; Microwave irradiation;
DOI:10.1021/op700009t

Reference yield:

: 30199-65-6
2-cyano-3-(3,4-dimethoxyphenylamino)acrylic acid ethyl ester

: 936833-38-4
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

: 4-[(3-amino-2-methylphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: biphenyl; diphenylether / 10 h / 200 °C / Inert atmosphere

2: trichlorophosphate / 2 h / Reflux

3: pyridine hydrochloride / 2-ethoxy-ethanol / 1 h / 210 °C / Microwave irradiation

With pyridine hydrochloride; trichlorophosphate; In 2-ethoxy-ethanol; diphenylether; biphenyl;
DOI:10.1021/op700009t

Reference yield:

: 6315-89-5
3,4-dimethoxyaniline

: 936833-38-4
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine

: 4-[(3-amino-2-methylphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 1.25 h / 100 - 125 °C

2: biphenyl; diphenylether / 10 h / 200 °C / Inert atmosphere

3: trichlorophosphate / 2 h / Reflux

4: pyridine hydrochloride / 2-ethoxy-ethanol / 1 h / 210 °C / Microwave irradiation

With pyridine hydrochloride; trichlorophosphate; In 2-ethoxy-ethanol; diphenylether; biphenyl; toluene;
DOI:10.1021/op700009t