214470-55-0

Basic information

• Product Name: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE
• Synonyms: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ;4-Chloro-3-cyano-6,7-dimethoxyquinoline;3-Quinolinecarbonitrile, 4-chloro-6,7-diMethoxy-; 214470-55-0
• CAS NO: 214470-55-0
• Molecular Formula: C₁₂H₉ClN₂O₂
• Molecular Weight: 248.66506
• Mol File: 214470-55-0.mol
• Article Data: 17

Chemical Properties

• Melting Point: 220-223 °C
• Boiling Point: 404.22 °C at 760 mmHg
• Flash Point: 198.266 °C
• Appearance: /
• Density: 1.361 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.68±0.41(Predicted)
• CAS DataBase Reference: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE(214470-55-0)
• EPA Substance Registry System: 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE(214470-55-0)

Safety Data

• Hazardous Substances Data: 214470-55-0(Hazardous Substances Data)

Usage

Uses

4-?Chloro-?6,?7-?dimethoxy-3-?quinolinecarbonitril?e is used as a reactant in the synthesis of Src kinase activity inhibitors.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 43, p. 3244, 2000 DOI: 10.1021/jm000206a

InChI:InChI=1/C12H9ClN2O2/c1-16-10-3-8-9(4-11(10)17-2)15-6-7(5-14)12(8)13/h3-4,6H,1-2H3

Upstream product

• 67-56-1 methanol 
• 263149-10-6 4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile 
• 50845-31-3 4-hydroxy-6,7-dimethoxy-quinoline-3-carbonitrile 
• 214470-52-7 1,4-dihydro-6,7-dimethoxy-4-oxo-quinoline-3-carbonitrile 
• 30199-65-6 2-cyano-3-(3,4-dimethoxyphenylamino)acrylic acid ethyl ester 
• 6315-89-5 3,4-dimethoxyaniline 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 

Relevant articles and documents

PHOSPHODIESTERASE INHIBITORS AND USE

The invention provides compounds that may inhibits to ENPP1, and are accordingly useful for treatment disorders related to ENPP1. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent disorders related to ENPP1.

3-AMINOTHIENO[3,2-c]QUINOLINE DERIVATIVES, METHODS OF PREPARATION AND USES

The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, and Y are as defined herein. Methods for preparing co

An efficient synthesis of dibenzo[c,f]-2,7-naphthyridine ring system through design of experiments

The dibenzo[c,f]-2,7-naphthyridine ring system was found to be of biological interest, but had limited synthetic accessibility. The initial compound of interest, 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3, 6-diamine, was obtained in 25% yie