4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide
CAS No.:1615250-01-5
Molecular Formula:C₂₆H₃₃N₃O₄S
Molecular Weight:483.632
Hs Code.:

Synonyms:4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

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Chemical Property of 4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

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Technology Process of 4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

There total 7 articles about 4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1629057-45-9
(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

: 98-59-9
p-toluenesulfonyl chloride

: 1615250-01-5
4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 87341-45-5
(2S)-N-(4-methylbenzyl) pyroglutamic acid

: 1615250-01-5
4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 104-81-4
4-Methylbenzyl bromide

: 1615250-01-5
4-methyl-N-(((R)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; water; sodium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017