(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one
CAS No.:1629057-45-9
Molecular Formula:C₁₉H₂₇N₃O₂
Molecular Weight:329.442
Hs Code.:

Synonyms:(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

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Chemical Property of (S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

Chemical Property:

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Technology Process of (S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

There total 6 articles about (S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1391739-80-2
tert-butyl ((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

: 1629057-45-9
(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 87341-45-5
(2S)-N-(4-methylbenzyl) pyroglutamic acid

: 1629057-45-9
(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With oxalyl dichloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 104-81-4
4-Methylbenzyl bromide

: 1629057-45-9
(S)-5-((S)-3-(aminomethyl)piperidine-1-carbonyl)-1-(4-methylbenzyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C

With oxalyl dichloride; water; sodium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017