(3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone

Base Information

• Chemical Name: (3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone
• CAS No.: 1268684-52-1
• Molecular Formula: C₂₅H₁₇FO₄
• Molecular Weight: 400.406
• Mol file: 1268684-52-1.mol

Synonyms:(3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone

Chemical Property of (3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone

There total 1 articles about (3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,9-dimethoxybenzo[b]naphtho[1,2-d]furan-5-carbonitrile (1079791-91-5) + 4-flourophenylmagnesium bromide (352-13-6) → (3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone (1268684-52-1)

Guidance literature:

3,9-dimethoxybenzo[b]naphtho[1,2-d]furan-5-carbonitrile; 4-flourophenylmagnesium bromide; With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 24h;

With hydrogenchloride; water; In tetrahydrofuran; for 48h; Reflux;

DOI:10.1039/c2ob26062j

Reference yield: 95.0%

(3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone (1268684-52-1) → (3,9-dihydroxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone (1268684-44-1)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 70 ℃; for 48h;

DOI:10.1039/c2ob26062j

Reference yield:

(3,9-methoxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-fluorophenyl)methanone (1268684-52-1) → (3,9-dihydroxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[1-methylpiperidine-4-yloxy]phenyl)methanone (1268684-50-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 48 h / 0 - 70 °C

2.1: potassium carbonate / ethanol / 24 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 30 h / 20 °C

3.2: 6 h

4.1: 5%-palladium/activated carbon; hydrogen; ammonium formate / ethanol; water; ethyl acetate / 3 h / Reflux

With 5%-palladium/activated carbon; hydrogen; ammonium formate; boron tribromide; sodium hydride; potassium carbonate; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/c2ob26062j

upstream raw materials:

3,9-dimethoxybenzo[b]naphtho[1,2-d]furan-5-carbonitrile

4-flourophenylmagnesium bromide

Downstream raw materials:

(3,9-dihydroxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[2-(piperidin-1-yl)ethoxy]phenyl)methanone

(3,9-dibenzyloxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[2-(N,Ndimethyl)ethoxy]phenyl)methanone

(3,9-dibenzyloxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[1-methylpiperidine-4-yloxy]phenyl)methanone

(3,9-dihydroxybenzo[b]naphtho[1,2-d]furan-5-yl)(4-[2-(piperidine-1-yl)ethoxy]phenyl)methanone