N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide
CAS No.:1425510-14-0
Molecular Formula:C₁₇H₁₃F₃N₂O₃
Molecular Weight:350.297
Hs Code.:

Synonyms:N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 95650-58-1
N-(4-ethynylphenyl)-2,2,2-trifluoroacetamide

: 120491-88-5
4-bromo-2,6-pyridinedimethanol

: 1425510-14-0
N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 55 ℃; for 19h; Inert atmosphere;

Reference yield:

: 14235-81-5
4-Ethynylaniline

: 1425510-14-0
N-(4-((2,6-bis(hydroxymethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.67 h / 20 °C / Cooling with ice

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 19 h / 55 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran;