3-CYCLOPENTYL-1-PROPYNE

Base Information

• Chemical Name: 3-CYCLOPENTYL-1-PROPYNE
• CAS No.: 116279-08-4
• Molecular Formula: C8H12
• Molecular Weight: 108.183
• Hs Code.: 29029000
• Mol file: 116279-08-4.mol

Synonyms:Cyclopentane,2-propynyl- (9CI); 3-Cyclopentyl-1-propyne; 3-Cyclopentylpropyne;Prop-2-ynylcyclopentane; Propargylcyclopentane

Chemical Property of 3-CYCLOPENTYL-1-PROPYNE

Chemical Property:

• Vapor Pressure: 11.3mmHg at 25°C
• Melting Point: 132-134 °C
• Refractive Index: n20/D 1.4490(lit.)
• Boiling Point: 132-134 °C(lit.)
• Flash Point: 20.3°C
• PSA: 0.00000
• Density: 0.854g/cm³
• LogP: 2.19990
• Solubility.: Not miscible or difficult to mix.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Cyclopentyl-1-propyne 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 10-22-41
• Safety Statements: 16-26-36/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Cyclopentylpropyne is a useful building block. Due to the fact that it has a terminal alkyne it can be used to explore regioselective reactions.

Technology Process of 3-CYCLOPENTYL-1-PROPYNE

There total 2 articles about 3-CYCLOPENTYL-1-PROPYNE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-3-cyclopentyl-propene → prop-2-yn-1-ylcyclopentane (116279-08-4)

Guidance literature:

With sodium amide; decalin; at 150 ℃;

Reference yield:

cyclopentylmagnesium bromide (33240-34-5) → prop-2-yn-1-ylcyclopentane (116279-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: NaNH₂; decalin / 150 °C

With diethyl ether; sodium amide; decalin;

Reference yield: 99.0%

4-amino-3-chloro-5-iodobenzoic acid methyl ester (1240113-63-6) + prop-2-yn-1-ylcyclopentane (116279-08-4) → 4-amino-3-chloro-5-(3-cyclopentyl-prop-1-ynyl)-benzoic acid methyl ester (1240113-74-9)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

cyclopentylmagnesium bromide

Downstream raw materials:

C₃₈H₅₀O₆

3-phenylthiopyridine

1-cyclopentyl-propan-2-one