(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

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Chemical Name:(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester
CAS No.:1026423-85-7
Molecular Formula:C₂₉H₃₂F₃NO₄S
Molecular Weight:547.639
Hs Code.:

Synonyms:(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

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Chemical Property of (5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

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Technology Process of (5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

There total 13 articles about (5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 1026423-85-7
(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Zn / CuCl / tetrahydrofuran / 16 h / 20 - 35 °C

2: H₂ / Pd/C / ethanol / 2068.59 Torr

3: 146.9 g / Amano Lipase PS / aq. phosphate buffer / 12 h / 20 °C / pH 7.0

4: 100 percent / chlorotrimethylsilane / 12 h / 20 °C

5: 96 percent / AlCl₃; EtSH / CH₂Cl₂ / 2.5 h / 10 °C

6: Cs₂CO₃ / dimethylformamide / 14 h / 20 - 80 °C

7: Cs₂CO₃ / dimethylformamide; H₂O / 16 h / 40 °C

8: 76 percent / H₂S; Et₂NH / dimethylformamide / 3 h / 60 °C

9: ethanol / 70 °C

With chloro-trimethyl-silane; aluminium trichloride; Amano Lipase PS; hydrogen sulfide; hydrogen; caesium carbonate; diethylamine; ethanethiol; zinc; palladium on activated charcoal; copper(l) chloride; In tetrahydrofuran; phosphate buffer; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Reformatsky reaction;
DOI:10.1021/jm061299k

Reference yield:

: 33148-47-9
4-allyloxy-benzonitrile

: 1026423-85-7
(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / 20 h / 200 °C

2: 99 percent / H₂ / Pd/C / ethanol / 20 h / 20 °C / 760 Torr

3: Cs₂CO₃ / dimethylformamide; H₂O / 16 h / 40 °C

4: 76 percent / H₂S; Et₂NH / dimethylformamide / 3 h / 60 °C

5: ethanol / 70 °C

With hydrogen sulfide; hydrogen; caesium carbonate; diethylamine; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide; 1: Claisen rearrangement;
DOI:10.1021/jm061299k

Reference yield:

: 21779-34-0
ethyl 2-[(1E)-5-methoxy-2,3-dihydro-1H-inden-1-ylidene]acetate

: 1026423-85-7
(5-{3-[2-propyl-4-(4-trifluoromethyl-thiazol-2-yl)-phenoxy]-propoxy}-indan-1-yl)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / Pd/C / ethanol / 2068.59 Torr

2: 146.9 g / Amano Lipase PS / aq. phosphate buffer / 12 h / 20 °C / pH 7.0

3: 100 percent / chlorotrimethylsilane / 12 h / 20 °C

4: 96 percent / AlCl₃; EtSH / CH₂Cl₂ / 2.5 h / 10 °C

5: Cs₂CO₃ / dimethylformamide / 14 h / 20 - 80 °C

6: Cs₂CO₃ / dimethylformamide; H₂O / 16 h / 40 °C

7: 76 percent / H₂S; Et₂NH / dimethylformamide / 3 h / 60 °C

8: ethanol / 70 °C

With chloro-trimethyl-silane; aluminium trichloride; Amano Lipase PS; hydrogen sulfide; hydrogen; caesium carbonate; diethylamine; ethanethiol; palladium on activated charcoal; In phosphate buffer; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061299k