2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

Base Information

Chemical Name:2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide
CAS No.:1365992-15-9
Molecular Formula:C₁₃H₅Cl₂F₂N₃O
Molecular Weight:328.105
Hs Code.:

Synonyms:2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

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Chemical Property of 2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

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Technology Process of 2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

There total 8 articles about 2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1365992-19-3
2-chloro-4-cyano-6-fluoro-benzamide

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365992-15-9
2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 4h; Inert atmosphere; Reflux;

Reference yield: 55.0%

: 1365992-14-8
2-chloro-N-(2-chloro-4-cyano-6-fluoro-benzoyl)-N-(2-chloro-3-fluoropyridin-4-yl)-4-cyano-6-fluorobenzamide

: 1365992-15-9
2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

Guidance literature:: With methanol; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 2.5h;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365992-15-9
2-chloro-N-(2-chloro-3-fluoro-pyridin-4-yl)-4-cyano-6-fluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With caesium carbonate; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene;