N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

Base Information

Chemical Name:N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide
CAS No.:1395412-77-7
Molecular Formula:C₂₁H₁₆ClF₃N₂O₂
Molecular Weight:420.818
Hs Code.:

Synonyms:N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

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Chemical Property of N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

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Technology Process of N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

There total 4 articles about N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1395412-76-6
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-isophthalamic acid methyl ester

: 1395412-77-7
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: N-[4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-isophthalamic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

With water; Rochelle's salt; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 958258-15-6
3-bromo-5-(trifluoromethyl)benzoyl chloride

: 1395412-77-7
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 1 h / -78 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 18 h / 100 °C / 60006 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; triethylamine; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1395412-77-7
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxymethyl-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 1 h / 100 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: 1 h / -78 °C

3.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 18 h / 100 °C / 60006 Torr

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; thionyl chloride; triethylamine; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethyl acetate;