(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

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Chemical Name:(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid
CAS No.:1187649-55-3
Molecular Formula:C₂₀H₂₄N₄O₇
Molecular Weight:432.433
Hs Code.:

Synonyms:(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

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Chemical Property of (S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

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Technology Process of (S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

There total 3 articles about (S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-3-amino-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid trifluoroacetate

: 1187649-55-3
(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: C₂₄H₃₂N₄O₇

: 1187649-55-3
(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

Guidance literature:: C₂₄H₃₂N₄O₇; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With di-tert-butyl dicarbonate; triethylamine; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2018.02.049

Reference yield:

: 18635-49-9
4-tert-butyl 1-methyl L-N-(tert-butoxycarbonyl)aspartate

: 1187649-55-3
(S)-3-(tert-butoxycarbonylamino)-3-(5-(4-(methoxycarbonylamino)phenyl)-6-oxo-1,6-dihydropyridazin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl methane phosphonate; n-butyllithium / tetrahydrofuran / -78 - 0 °C

1.2: 0.5 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With n-butyllithium; trifluoroacetic acid; dimethyl methane phosphonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2018.02.049