(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

Base Information

Chemical Name:(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid
CAS No.:1187649-00-8
Molecular Formula:C₂₀H₂₃ClN₄O₆
Molecular Weight:450.879
Hs Code.:

Synonyms:(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

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Chemical Property of (S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

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Technology Process of (S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

There total 5 articles about (S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₂₁H₂₆N₄O₇

: 1187649-00-8
(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

Guidance literature:: C₂₁H₂₆N₄O₇; With trichlorophosphate; In chloroform;

With di-tert-butyl dicarbonate; triethylamine; In dichloromethane;

With lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2018.02.049

Reference yield:

: 1187648-99-2
(S)-methyl 3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoate

: 1187649-00-8
(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

Guidance literature:: (S)-methyl 3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; methanol; Inert atmosphere;

Reference yield:

: 18635-49-9
4-tert-butyl 1-methyl L-N-(tert-butoxycarbonyl)aspartate

: 1187649-00-8
(S)-3-(tert-butoxycarbonylamino)-3-(6-chloro-5-(4-(methoxycarbonylamino)phenyl)pyridazin-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl methane phosphonate; n-butyllithium / tetrahydrofuran / -78 - 0 °C

1.2: 0.5 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: diazomethyl-trimethyl-silane / dichloromethane

4.1: trichlorophosphate / chloroform

With n-butyllithium; trifluoroacetic acid; dimethyl methane phosphonate; trichlorophosphate; diazomethyl-trimethyl-silane; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1016/j.bmcl.2018.02.049