N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Base Information

Chemical Name:N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide
CAS No.:1027344-89-3
Molecular Formula:C₄₃H₄₅ClN₈O₄S₂
Molecular Weight:837.466
Hs Code.:

N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Synonyms:N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Suppliers and Price of N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

There total 12 articles about N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 406233-35-0
4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide

: 1027345-24-9
4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

: 1027344-89-3
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Guidance literature:: With copper(l) iodide; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 150 - 180 ℃; for 0.75h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 1027345-15-8
tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate

: 1027344-89-3
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 2 h / Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

5.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

6.1: hydrogenchloride; water; acetic acid / 9 h / 130 °C

7.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 21.25 h / 70 °C / Inert atmosphere

8.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; iron; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1021/jm101596e

Reference yield:

: 1027345-29-4
4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile

: 1027344-89-3
N-{7-[4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl]quinazolin-4-yl}-4-(((R)-3-dimethylamino-1-(phenylsulfanylmethyl)prop-1-yl)amino)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

3.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

4.1: hydrogenchloride; water; acetic acid / 9 h / 130 °C

5.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 21.25 h / 70 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; iron; sodium carbonate; potassium carbonate; acetic acid; N,N-dimethyl-formamide; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm101596e