4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

Base Information

Chemical Name:4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline
CAS No.:1027345-24-9
Molecular Formula:C₂₅H₂₂Cl₂N₄
Molecular Weight:449.382
Hs Code.:

Synonyms:4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

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Chemical Property of 4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

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Technology Process of 4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

There total 20 articles about 4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1027345-23-8
7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4(3H)-one

: 1027345-24-9
4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

Guidance literature:: With trichlorophosphate; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; at 70 ℃; for 21.25h; Product distribution / selectivity;

Reference yield: 55.0%

: 1027345-23-8
7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-ol

: 1027345-24-9
4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

Guidance literature:: 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-ol; With N,N-dimethyl-formamide; trichlorophosphate; In 1,2-dichloro-ethane; at 70 ℃; for 21.25h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm101596e

Reference yield:

: 1027345-15-8
tert-butyl 4-(4-cyano-3-nitrophenyl)piperazine-1-carboxylate

: 1027345-24-9
4-chloro-7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetonitrile / 2 h / Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

3.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

5.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

6.1: hydrogenchloride; water; acetic acid / 9 h / 130 °C

7.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 21.25 h / 70 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; iron; sodium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1021/jm101596e