(3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one

Base Information

• Chemical Name: (3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one
• CAS No.: 172510-04-2
• Molecular Formula: C₃₀H₂₄N₂O₄
• Molecular Weight: 476.532
• Mol file: 172510-04-2.mol

Synonyms:(3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one

Chemical Property of (3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one

There total 1 articles about (3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-3-benzoyl-4-methylene-2-phenyloxazolidin-5-one (147092-29-3) + C,N-diphenylnitrone (201024-81-9) → (3R,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one + (3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one (172510-04-2)

Guidance literature:

In dichloromethane; at 60 ℃; for 72h; Yield given. Yields of byproduct given;

DOI:10.1071/CH9951511

Reference yield: 47.0%

(3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one (172510-04-2) → N-benzylbenzamide (1485-70-7) + (2'R,4'S)-N-(1',4'-Diphenylazetidin-2'-yl)benzamide

Guidance literature:

With hydrogen; palladium dihydroxide; In ethyl acetate; for 5h; under 760 Torr; Ambient temperature;

DOI:10.1071/CH9951511

Reference yield:

(3S,5S,7R)-6-Benzoyl-2,3,7-triphenyl-1,8-dioxa-2,6-diazaspiro<4.4>nonan-9-one (172510-04-2) → (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-5-benzoylamino-2,3-diphenyl-isoxazolidin-5-ylmethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaBH₄ / CH₂Cl₂; methanol / 16 h / Ambient temperature

2: 61 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1071/CH9951511

upstream raw materials:

(2R)-3-benzoyl-4-methylene-2-phenyloxazolidin-5-one

C,N-diphenylnitrone

Downstream raw materials:

N-benzylbenzamide