2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

Base Information

Chemical Name:2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid
CAS No.:1297275-57-0
Molecular Formula:C₂₄H₁₉F₃N₂O₃
Molecular Weight:440.422
Hs Code.:

Synonyms:2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

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Chemical Property of 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

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Technology Process of 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

There total 4 articles about 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1297283-53-4
methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

: 1297275-57-0
2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 0.916667h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 399-72-4
5-fluoro-2-methyl-1H-indole

: 1297275-57-0
2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 0 °C / Inert atmosphere; Reflux

3: sodium iodide / acetonitrile / Reflux

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 0.92 h / 20 °C

With triethylsilane; lithium hydroxide monohydrate; water; sodium hydride; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1297283-51-2
methyl 2-(5-fluoro-3-((6-methoxypyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

: 1297275-57-0
2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium iodide / acetonitrile / Reflux

2: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 0.92 h / 20 °C

With lithium hydroxide monohydrate; water; sodium iodide; In tetrahydrofuran; methanol; acetonitrile;