methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

Base Information

Chemical Name:methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate
CAS No.:1297283-53-4
Molecular Formula:C₂₅H₂₁F₃N₂O₃
Molecular Weight:454.449
Hs Code.:

Synonyms:methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

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Chemical Property of methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

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Technology Process of methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

There total 3 articles about methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1297283-51-2
methyl 2-(5-fluoro-3-((6-methoxypyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetate

: 23915-07-3
1-(bromomethyl)-2,4-difluorobenzene

: 1297283-53-4
methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: With sodium iodide; In acetonitrile; Reflux;

Reference yield:

: 646515-44-8
methyl 2-(5-fluoro-2-methyl-1H-indol-1-yl)acetate

: 1297283-53-4
methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 0 °C / Inert atmosphere; Reflux

2: sodium iodide / acetonitrile / Reflux

With triethylsilane; trifluoroacetic acid; sodium iodide; In 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 399-72-4
5-fluoro-2-methyl-1H-indole

: 1297283-53-4
methyl 2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid; triethylsilane / 1,2-dichloro-ethane / 0 °C / Inert atmosphere; Reflux

3: sodium iodide / acetonitrile / Reflux

With triethylsilane; sodium hydride; trifluoroacetic acid; sodium iodide; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;