(4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one

Base Information

• Chemical Name: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one
• CAS No.: 367952-46-3
• Molecular Formula: C₁₃H₁₀ClF₆NO₂
• Molecular Weight: 361.671
• Mol file: 367952-46-3.mol

Synonyms:(4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one

Chemical Property of (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one

There total 2 articles about (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one (150582-52-8) → (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one (367952-46-3)

Guidance literature:

With thionyl chloride;

DOI:10.1055/s-2001-16091

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one (367952-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / dimethylsulfoxide

2: 65 percent / SOCl₂

With thionyl chloride; In dimethyl sulfoxide;

DOI:10.1055/s-2001-16091

Reference yield: 81.0%

(4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one (367952-46-3) → (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-methyl-1,3-oxazolidin-5-one (367952-49-6)

Guidance literature:

With triethylsilane; trifluoroacetic acid;

DOI:10.1055/s-2001-16091

upstream raw materials:

formaldehyd

(4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one

L-phenylalanine

Downstream raw materials:

(4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-methyl-1,3-oxazolidin-5-one

N-Methyl-L-phenylalanine

L-Tic-OH