N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

Base Information

Chemical Name:N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide
CAS No.:1231880-84-4
Molecular Formula:C₂₀H₂₀FN₃OS
Molecular Weight:369.463
Hs Code.:

Synonyms:N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

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Chemical Property of N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

Chemical Property:

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Technology Process of N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

There total 4 articles about N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 365428-84-8
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-amine

: 141-75-3
butyryl chloride

: 1231880-84-4
N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1231880-43-5
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine

: 1231880-84-4
N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane; water / 15 - 20 °C

2.1: trichlorophosphate / 8 h / Reflux

3.1: 16 h / 180 °C

4.1: sulfuric acid / 20 °C / Ice cooling

4.2: pH 10 / Ice water

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With sulfuric acid; dihydrogen peroxide; methyltrioxorhenium(VII); N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1373318-18-3
4-[2-ethyl-4-(4-fluorophenyl)-1,3-thiazol-5-yl]pyridine 1-oxide

: 1231880-84-4
N-{4-[2-ethyl-4-(4-fluoro-phenyl)-thiazol-5-yl]-pyridin-2-yl}-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 8 h / Reflux

2.1: 16 h / 180 °C

3.1: sulfuric acid / 20 °C / Ice cooling

3.2: pH 10 / Ice water

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran;